منابع مشابه
Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity.
To assess the contribution of the human kidney to gluconeogenesis (GN) and its role in conversion of glutamine and alanine to glucose, we used a combination of isotopic and organ balance techniques in nine normal postabsorptive volunteers and measured both overall and renal incorporation of these precursors into glucose before and after infusion of epinephrine. In the postabsorptive basal state...
متن کاملUse of liver snips for studies on gluconeogenesis
measured in perchloric acid extracts of medium by the hexokinase/glucose-6-phosphate dehydrogenase method (Bergmeyer et al., 1974) and protein in the cell pellets by the method of Lowry et al. (1951). Figures show mean values +s.E.M. and data were analysed using Student’s t-test. Fig. la shows that in CdC12-pretreated rats, gluconeogenesis from pyruvate is stimulated by 35% (P<0.05) compared wi...
متن کاملControl of Gluconeogenesis in Rat Liver Cells
Control of gluconeogenesis from lactate was studied by titrating rat liver cells with lactate and pyruvate in a ratio of 1 O : l in a perifusion system. At different steady states of glucose formation, the concentration of key gluconeogenic intermediates was measured and plotted against gluconeogenic flux (Jglucoee). Complete saturation was observed only in the plot relating JglUcto the extrace...
متن کاملglycolysis/gluconeogenesis in regenerating rat liver
Levels of mRNA for glucokinase, L-pyruvate kinase, fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase were analysed during liver regeneration. Levels of mRNA for glycolytic enzymes (glucokinase and L-pyruvate kinase) decreased rapidly after partial hepatectomy. Glucokinase mRNA increased at 16-24 h, returning to normal values after this time. L-pyruvate kinase mRNA recovered cont...
متن کاملGluconeogenesis in Neonatal Piglet Liver 1
The gluconeogenic capacity of livers from day old and 5-day-old piglets has been studied. The data show infused piglets and perfused livers convert lactate to glucose. Studies with isolated liver mitochondria show a large capacity to flux pyruvate through the pyruvate carboxylase reaction causing an accumulation of malate, citrate and phosphoenolypyruvate. Factors that affect accumulation of ma...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1976
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf01220631